Blood Product Solution Tank

WhatsApp/WeChat: +8617355715967
E-mail: [email protected]

Overview

Living organisms cannot survive without blood, making the research and development of blood products particularly important. In layman’s terms, a blood product solution preparation system refers to equipment and supporting control systems designed for manufacturing various plasma protein products, including human albumin, placental human albumin, intravenous human immunoglobulin, intramuscular human immunoglobulin, and other similar products.

The blood product solution preparation system has evolved into an integrated solution control module. The solution tanks adopt advanced pharmaceutical formulation processes, while the system pipelines and controls feature hygienic designs with no dead angles, enabling easy cleaning and sterilization. These features ensure uniform mixing, high energy efficiency, and consistent product quality, thus guaranteeing the homogeneity and reliability of the final products.

Distinguishing Feature

The core functions of a blood product solution preparation system—including solution formulation, aseptic filtration, dynamic buffering, liquid transportation, and process control—are critical for ensuring product sterility and preparing liquids of standard concentration. Its main features include:

1. GMP-Compliant Solution Tank Design

Tanks are designed to GMP standards for hygienic cleanliness, with no residue, sterilization/cleaning dead angles, or cold spots during sterilization to ensure system-wide asepsis.
Our company’s concentrated/dilute solution tanks feature 360° dead-angle-free cleaning and in-situ sterilization, manufactured from hygienic stainless steel 304/316L.
Internal surfaces are mirror-polished to 0.22μm precision; pipe connections use drawn flanging to eliminate dead angles. External surfaces undergo electrolytic polishing, mechanical matt finishing, or sandblasting.

2. High-Precision Metering and Agitation

Metering accuracy is ensured via weighing modules and automatic 液位 / 流量 (level/flow) control modules for volume/concentration consistency.
The agitation system features aseptic uniform mixing design to ensure complete dissolution, with efficient solution preparation.

3. Hygienic Pipeline Design

Pipelines have clear flow paths and sanitary drainable designs:
- Horizontal pipes have >1% slope for complete drainage.
- Diaphragm valves on horizontal pipes are installed at an incline to prevent residue.
Contact surfaces (typically 316L stainless steel) are mechanically/electrolytically polished. The entire system (tanks, pipes, valves, instruments) supports effective CIP and SIP.

4. Automated Process Control

Adjustable stirring speed with automatic liquid metering (dual control via level and weight).
In-line temperature control/display supports heating, cooling, and insulation for uniform temperature control.

5. Welding and Quality Assurance

Full-automatic orbital welding with 99.999% high-purity argon shielding prevents oxidation.
Welds undergo endoscope and radiographic inspection per client URS, ensuring pressure/temperature requirements.

6. Compliance Standards

Design is based on:

GB 150-2011 Steel Pressure Vessels
HG 20584/20583/20569 (chemical vessel standards)
EU GMP, SFDA GMP 2010, ISO 14644-1, GB 50457-2008, GAMP

7. Validation Support

We assist with RA/DQ/IQ/OQ, providing technical documentation as required.
Factory acceptance tests include:
- Tank heating/cooling rate testing
- Thermal insulation testing
- SIP capability testing (thermal distribution, BI challenge, pipeline residue check)